Well, if you under-inflate a tyre, the outcome can be a blowout, possibly writing the vehicle off, maybe killing a few people.
Over-inflate it and you risk a harsh, noisy ride, poor grip and uneven wear.
So if you don't know what the pressure should be, err on the side of caution and blow it up to higher than seems likely to be correct.
It's extremely unlikely that 65psi is the correct pressure for your van.
Without knowing the actual axle weights of it loaded, it's not possible to calculate. So the tyre maker, the chassis maker, the converter... None of them can really know what the pressure should be, so they guess. And add a bit for luck.
The neatly round figure tells you the pressure is an arbitrary number.
Of course, when you drive, the tyres warm, the pressure rises. That means that precise calculations are a bit of a red herring
Some old-school truck drivers reckon on the rule of 6 or 7psi. If your pressures rise by less than that when driving, they were too hard. If they rise more than that, they were too soft. However, that presupposes a set temperature from cold, I guess. And it assumes your tyres are full of air, not pure nitrogen.